I downloaded OpenTK from SVN and I found this problem when trying to run an application in Ubuntu 11.10
Unhandled Exception: System.TypeInitializationException: An exception was thrown by the type initializer for OpenTK.Input.Mouse ---> System.DllNotFoundException: libXi
The solution is to add this line
<dllmap os="linux" dll="libXi" target="libXi.so.6"/>
to file 'OpenTK.dll.config'.